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Bloorview Research Institute

Scientist Profiles

Name: Evdokia Anagnostou

Title: Clinician Scientist, Bloorview Research Institute

Theme: Evaluation of care

Education:

M.D. Medicine, McGill University (1998)
B.Sc Chemistry, Stevens Institute of technology, 1994
Grad Certificate, Chemical Physiology, Stevens Institute of technology, 1994

University Position:

Assistant Professor, Department of Peadiatrics, University of Toronto

Research Interests:

Neuropsychopharmacology of autism
Neuroimaging of frontostriatal circuitry and social cognition networks in autism

Current Funding:

Title: A double blind placebo controlled trial of memantine targeting motor skills in autism ($108,986)
Role: PI
Agency: Autism Speaks

Title: Brain Glutamate Concentrations in Autistic Adolescents by Magnetic Resonance Spectroscopy ($60,000)
Role: PI
Agency: NARSAD

Title: Brain Glutamate Concentrations in Autistic Children by Magnetic Resonance Spectroscopy ($109,582)
Role: PI
Agency: Autism Speaks

Title: “fMRI for the Study of Response Inhibition, and Face and Linguistic Processing in Autism” ($172,125)
Role: PI
Agency: Seaver Foundation

Title: “fMRI Study of the Effect of Intravenous Oxytocin vs. Placebo on Response Inhibition and Face Processing in Autism”
Role: PI
Agency: Mount Sinai School of Medicine GCRC

Title: Greater New York Autism Research Center of Excellence ($6.2mil, no cost extension)
Role: Co-Investigator (PI: Hollander)
Agency: NIMH

Title: Intranasal oxytocin for the treatment of social cognition deficits and repetitive behaviors in adults
Role: PI
Agency: Mount Sinai School of Medicine GCRC

Title: Mediators of Motor skill and Praxis in adults with autism spectrum disorder ($83,104)
Role: co-Investigator (PI: Latha Soorya, PhD)
Agency: Autism Speaks

Selected Peer-Reviewed Journal Publications:

Anagnostou E, Miller SP, Guiot MC, Karpati G, Simard L, Dilenge ME, Shevell MI. Type 1 Spinal muscular atrophy may mimic sensory-motor axonal neuropathy. J Child Neurol 2005 20:147-50

Hollander E, Anagnostou E, Chaplin B, Esposito K, Haznedar M, Licalzi E et al. Striatal Volume on MRI and repetitive behaviors in autism. Biological Psychiatry 2005;58:226-32

Hollander E, Soorya L, Wasserman S, Esposito K, Chaplin W, Anagnostou E. Divalproex sodium vs. placebo in the treatment of repetitive behaviours in autism spectrum disorder. Int J Neuropsychopharmacol. 2006;9:209-13

Anagnostou E, Hollander E. Treatment of repetitive behaviors in autism. Current psychiatry, 2006 5:55-64

Anagnostou E., Esposito K., Soorya L., Chaplin W., Wasserman S., Hollander E. Divalproex vs. Placebo Reduces Irritability associated with Fluoxetine administration in autism. Journal of Clinical Psychopharmacology , 2006; 26:444-6

Wasserman S, Iyengar R, Chaplin WF, Watner D, Waldoks SE, Anagnostou E, Soorya L, Hollander E. Levetiracetam versus placebo in childhood and adolescent autism: a double-blind placebo-controlled study. Int Clin Psychopharmacol. 2006; 21:363-7.

Hollander E, Bartz J, Chaplin W, Phillips A, Sumner J, Soorya L, Anagnostou E, Wasserman S Oxytocin Increases Retention of Social Cognition in Autism. Biol Psychiatry. 2007 15;6:498-503

Guiqing Cai, Lisa Edelmann, Juliet E Goldsmith, Ninette Cohen, Alisa Nakamine, Jennifer G Reichert, Ellen J Hoffman, Danielle M Zurawiechi, Jeremy M Silverman, Eric Hollander, Latha Soorya, Evdokia Anagnostou, Catalina Betancur and Joseph D Buxbaum. Multiplex ligation-dependent probe amplification for genetic screening in autism spectrum disorders: Efficient identification of known microduplications and identification of a novel microduplication in ASMT. BMC Medical Genomics (In press)

Bryan H. King, M.D.*; Eric Hollander, M.D.; Linmarie Sikich, M.D.; James T. McCracken, M.D.; Lawrence Scahill, M.S.N., Ph.D.; Joel D. Bregman, M.D.; Craig L. Donnelly, M.D.; Evdokia Anagnostou, M.D; Kimberly Dukes, Ph.D.; Lisa Sullivan, Ph.D.; Deborah Hirtz, M.D.; Ann Wagner, Ph.D.; Louise Ritz, M.B.A.; and the STAART Psychopharmacology Network. No effect of Citalopram vs Placebo for Children and Adolescents with Autism Spectrum Disorders and marked levels of repetitive bejaviors. (Accepted for publication, Archives of general psychiatry)

Contact Information:
Bloorview Research Institute,
Bloorview Kids Rehab
150 Kilgour Road
Toronto, Ontario M4G 1R8

Tel: 416-425-6220, extension 6005

E-mail: eanagnostou at bloorview dot ca (see Note below)*

*Note: Copy the above e-mail address(es) into the To field of your e-mail message and reconstruct the e-mail address(es) by removing the spaces and replacing the “at” and “dot” with the proper symbols (@ and .) respectively.

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